Weight Loss

Fact or fable? Once you've been overweight, losing weight is harder

13 January 2024
Alex Schulz

Do people who have been overweight find it harder to maintain their weight?

We have all experienced the frustrating cycle: losing weight, gaining it back, and then trying to lose it again. It's like an endless roller coaster ride, with our fat cells seemingly begging for more. But scientists now warn that this battle against the yo-yo is not just a mental challenge but is also influenced by biological factors that work against us.

The memory of fat cells

The memory of fat cells, also known as adipocyte memory, refers to the phenomenon where fat cells in the body seem to retain a 'memory' of previous periods of weight gain and loss. This means that even after someone has lost weight, the fat cells in their body tend to grow and fill with fat again when there is an excess of calories consumed.

During periods of overeating and weight gain, the fat cells in the body increase in size and number. These fat cells store excess calories in the form of fats. When someone then loses weight, these fat cells shrink as they release the stored fat for energy. However, even after the fat cells have shrunk, they seem to retain a kind of 'memory' of their previous size and remain sensitive to storing fat during future weight gain.

This phenomenon has important implications for weight management. People who have been obese before often have a greater tendency to gain weight and find it more challenging to maintain their weight, even after losing weight. The adipocyte memory can cause these individuals to regain weight more quickly and make it harder to sustain fat loss.

Although the exact mechanism behind adipocyte memory is not yet fully understood, studies suggest that epigenetic changes may play a role. These epigenetic changes can cause fat cells to retain a 'memory' of previous periods of weight gain and loss, influencing the tendency to gain weight in the future.

Mental and genetic factors that hinder maintaining a healthy weight

Mental and genetic factors play a crucial role for people who have been overweight before and find it difficult to maintain their weight. These factors can pose significant challenges to maintaining long-term weight loss, even after successfully losing weight.

An important mental factor is the psychological response to weight loss and weight management. People who have been overweight before may experience feelings of anxiety, stress, and frustration around eating and weight. These emotions can lead to binge eating, emotional eating, and other dysfunctional eating habits, making it difficult to maintain weight.

Additionally, genetic factors play a role in determining a person's weight and the tendency to regain weight after losing it. Genetic variants related to metabolism, fat storage, appetite regulation, and physical activity can all contribute to the susceptibility to weight gain. People who have been overweight before may have a genetic predisposition that makes them prone to obesity and difficulties in maintaining weight loss.

Moreover, the genetic factors that contributed to the initial overweight condition do not necessarily disappear after losing weight. This genetic predisposition can persist and continue to influence appetite regulation, metabolism, and fat storage even after weight loss. This can result in an increased risk of relapse and the yo-yo effect, where people repeatedly lose and regain weight in a vicious cycle.

Conclusion

Backed by scientific research, we can unfortunately confirm that people who have been overweight before find it harder to maintain their weight. It's not just the fat cells that keep us in the grip of the yo-yo effect. Mental and genetic factors can also contribute to the difficulties in maintaining weight for those who have been overweight before.

This of course doesn't mean you should give up on losing fat or maintaining a healthy weight. It does mean that you will probably have to put in a bit more effort.