The Brain

Do you have blue eyes? Then you might handle alcohol better, scientists say..

1 February 2023
Sophie de Boer

A remarkable finding has emerged from science: scientists claim that people with blue eyes can handle alcohol better. Researchers suggest there is more behind those bright blue eyes than we thought.

The biological basis

But how can the color of your eyes influence your ability to process alcohol? Well, the answer lies in genetics. People with blue eyes generally have less melanin in their iris, the pigment that determines the color of our eyes. And guess what? This lack of melanin seems to play a role in how our bodies metabolize alcohol. A lower amount of melanin can result in faster alcohol metabolism. This can lead to a higher tolerance for alcohol in people with blue eyes.

Evolution and biology

But let's not forget that evolution might also play a role in this connection.

In the Middle Ages, clean drinking water in Northern Europe was a scarce commodity. Many people did not have access to reliable clean water because sources were often contaminated by human waste, animals, or other pollutants. As a result, drinking water was often risky and could lead to diseases such as dysentery, cholera, and typhus.

To circumvent this problem, people relied on alternative beverages such as beer. Beer was considered safer to drink because the brewing process involved boiling water, which helped kill disease-causing microorganisms. Additionally, beer contained calories and nutrients, making it a valuable food source.

Interestingly, beer consumption was not limited to adults; even children drank beer as part of their daily diet. This led to an interesting evolutionary pressure on the human population.

Human populations that consumed beer as a significant source of hydration over many generations may have developed genetic adaptations that helped them better handle the effects of alcohol. One of the key mechanisms involved are enzymes responsible for breaking down and processing alcohol in the body.

One of these enzymes is alcohol dehydrogenase (ADH), which is responsible for the first step in breaking down alcohol into acetaldehyde. Acetaldehyde is then converted into acetate by the enzyme aldehyde dehydrogenase (ALDH). People with genetic variants resulting in a more efficient form of these enzymes can break down and process alcohol faster, thereby experiencing fewer negative effects, such as hangovers.

From an evolutionary perspective, populations frequently exposed to alcohol through beer consumption may have had a selective advantage if they possessed genetic variants that helped them process alcohol more efficiently. This could have contributed to the emergence and spread of these genetic variants within those populations.

In short, in the Middle Ages, the lack of access to clean water and the subsequent reliance on beer as a beverage may have led to evolutionary selection that contributed to some people's ability to better digest and process alcohol. Enzymes such as ADH and ALDH play a crucial role in breaking down alcohol in the body.

This genetic predisposition within a population with many blue-eyed individuals can quickly yield a correlation, although it is not necessarily causal.

Conclusion

So, does this mean that if you have blue eyes, you are on your way to becoming an alcoholic? Absolutely not! It is important to remember that genetics is only one factor in a complex web of biological, psychological, and social influences on our behavior. So, while it may be fun to know that you might have a slightly higher tolerance for that glass of wine, it does not mean you should let yourself get carried away.