The Brain

How trauma can be passed on to future generations through our DNA

11 September 2024
Jacob Müller

Imagine that the traumas of your grandparents, or even earlier generations, might still be affecting your body and mind through your DNA. It sounds like something out of a science fiction story, but research suggests that the past might be much closer than we think.

Scientists have discovered that traumas can be passed down through our DNA to future generations. This means that the scars of experiences like war, poverty, or violence can be embedded not only psychologically but also physically in our genetic material.

How does this work? And what does it mean for our understanding of heredity and mental health?

Experiments

In a fascinating experiment, male mice were exposed to the scent of a specific chemical along with an electric shock. Over time, the mice learned to associate the scent with pain and showed an anxiety response when they smelled it.

Surprisingly, their offspring, who had never experienced the scent or the shock, also exhibited anxiety to the same scent. This indicates that trauma was passed down through epigenetic mechanisms.

Another notable study involved female mice exposed to extreme stress during pregnancy. These mothers showed increased stress levels and behavioral changes. Remarkably, their offspring, although not exposed to stress during pregnancy, exhibited increased stress sensitivity and behavioral abnormalities.

The second generation of mice had altered cortisol levels and changes in gene expression related to stress regulation, such as the NR3C1 gene. This provides strong evidence for the transmission of stress and trauma through epigenetic changes.

The Impact of epigenetics

Epigenetics is a fascinating field of biology that explores how environmental factors can influence gene expression without changing the genetic code itself. Instead, epigenetics determines how active or inactive certain genes are. This can affect various aspects of health, such as your weight, your lifespan, and trauma transmission.

Through epigenetic mechanisms, traumas can be passed on to future generations via DNA. Epigenetic changes affect how cells "read" and respond to genes, allowing physical and psychological responses to stress or trauma to be inherited through sperm and eggs.

Human studies

A concrete example in humans is research on the descendants of Holocaust survivors. Studies have shown that these individuals exhibit increased stress sensitivity, linked to changes in cortisol production due to their parents' traumatic experiences.

Another example is from research on those who lived through the Dutch Hunger Winter (1944-1945). Babies born during this period showed an increased risk of metabolic disorders like diabetes and obesity, as a result of their mothers' extreme hunger. These changes were then passed on to their own children.

Studies on American slavery and the traumas of indigenous communities also explore this phenomenon. It is suggested that the effects of generations of oppression and trauma may contribute to ongoing health issues in these communities, such as increased risks of heart disease and psychological disorders.

What scientists say:

"Epigenetic changes explain how traumatic experiences, even without genetic mutations, can appear in later generations." - Rachel Yehuda, psychiatrist and expert in trauma and epigenetics.
"What we’ve discovered is that traumas can have a lasting impact on sperm or eggs, meaning that descendants carry a molecular 'memory' of those traumas." - Isabelle Mansuy, neuro-epigeneticist at the University of Zurich.
"Our studies with mice show that parental traumatic experiences can cause behavioral and epigenetic changes in their offspring, even without direct exposure to the original stress." - Brian Dias, neuroscientist at Emory University.

Conclusion

The idea that our ancestors' traumas might be stored in our DNA sheds new light on our psyche and health. What was once thought to be purely about physical traits is now revealed to also include experiences and emotions.

This raises questions about how we address trauma, not only for ourselves but for future generations. However, it also offers hope: if negative experiences can be transmitted, perhaps so can resilience, healing, and growth..