The Brain

The dangers of 5-HTP

12 November 2023
Sophie de Boer

In a society where stress and anxiety are common challenges, many people seek natural ways to improve their mood. One popular supplement is 5-hydroxytryptophan (5-HTP), which is praised for its ability to boost serotonin production. However, beneath the calm surface of 5-HTP may lie potential dangers.

What do scientists say about the dangers of 5-HTP?

The role of 5-HTP in the body

Before diving deeper, it's important to understand what 5-HTP is and how it works. 5-HTP is a naturally occurring amino acid that is a precursor to serotonin, a neurotransmitter involved in regulating mood, sleep, and appetite. By taking 5-HTP, people often hope to increase their serotonin levels, which can result in an improved mood and a sense of well-being.

Risks of 5-HTP

1. 5-HTP and eosinophilia-myalgia syndrome (EMS)

One of the most severe side effects associated with the use of 5-HTP is eosinophilia-myalgia syndrome (EMS), a rare but potentially life-threatening condition. EMS is characterized by severe muscle pain, weakness, and other symptoms, and there have been reported cases of people developing EMS after using 5-HTP supplements.

2. 5-HTP and interactions with medications

5-HTP can interact with various medications, particularly those that affect serotonin production in the brain. Combining 5-HTP with antidepressants such as selective serotonin reuptake inhibitors (SSRIs) can lead to an excess of serotonin in the brain, which can be potentially dangerous and result in serotonin syndrome.

3. 5-HTP and dopamine imbalance

Although 5-HTP is primarily related to serotonin, there is some evidence suggesting that its use can affect levels of dopamine, another crucial neurotransmitter. Disrupting the balance between serotonin and dopamine in the brain can lead to mood disorders and other neurological problems.

Conclusion

While 5-HTP may seem like a promising supplement for improving mood and well-being at first glance, it is important to take its potential risks and side effects seriously. The use of 5-HTP can lead to severe complications such as eosinophilia-myalgia syndrome (EMS) and can interact with certain medications, leading to dangerous side effects. Additionally, using 5-HTP can disrupt the balance between serotonin and dopamine in the brain, resulting in mood disorders and other neurological issues. If you are considering using 5-HTP as a supplement, it is important to discuss it with your doctor first and evaluate the potential risks.